RE-B FORTE Tablet
DESCRIPTION
Each film coated tablet contains:
Thiamine mononitrate (B1) 250 mg, pyridoxine (B6) hydrochloride 250 mg, cyanocobalamin (B12) 1,000 mcg. Action RE-B FORTE is a combination of the 3 essential neurotropic vitamin B group.
PHARMACOLOGY :
Thiamine is involved in carbohydrate metabolism and in nerve transmission. Thiamine combines with adenosine triphosphate (ATP) to form a coenzyme, thiamine pyrophosphate (thiamine diphosphate, cocarboxylase), which is necessary for carbohydrate metabolism.
Pyridoxine is involved in amino acid metabolism and in protein metabolism. Pyridoxine is converted in erythrocytes to pyridoxal phosphate and to a lesser extent pyridoxamine phosphate which acts as coenzymes for various metabolic functions affecting protein, carbohydrate and lipid utilization. Pyridoxine is involved in conversion of tryptophan to niacin or serotonin, breakdown of glycogen to glucose-1-phosphate, conversion of oxalate to glycine, synthesis of gamma aminobutyric acid (GABA) within the CNS, and synthesis of heme.
Cyanocobalamin influences hematopoiesis. It is involved in formation and metabolism of purities and pyrimidines and in the synthesis of nucleoproteins. Vitamin B12 acts as coenzyme for various metabolic functions, including fat and carbohydrate metabolism and protein synthesis. It is necessary for growth, cell replication, hematopoiesis and nucleoprotein and myelin synthesis, largely due to its effects on metabolism of methionine, folic acid and malonic acid.
INDICATIONS/USES :
For neurological and other disorders associated with disturbance of the nerve cell metabolism in which high-dose B-complex vitamins play a role. These include: polyneuritis (of toxic and nontoxic etiology); neuralgias e.g. lumbalgia, trigeminal neuralgia, shoulder-arm syndrome, herpes zoster, cervical syndrome, ischialgia, etc; diabetic neuropathy; metabolic and neurophatic changes due to pregnancy and oral contraceptives, convalescence.
DOSAGE/DIRECTIONS
Therapeutic dose: 2-3 tablet daily for 7-10 days.
Maintenance dose: 1 tablet daily. RE-B FORTE should be swallowed whole, during or immediately after meals. Do not take the tablets on an empty stomach.
CONTRAINDICATION
Past history of allergy to cobalamins. Known intolerance to thiamine. Known hypersensitivity to pyridoxine or any of the ingredients in the product.
SPECIAL PRECAUTION
Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibly of masking symptoms of subacute degeneration of the spinal cord.
Cyanocobalamin is not suitable form of vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin. Long term administration of large doses of pyridoxine is associated with the development of severe peripheral neuropathies. This may occur with doses in excess of about 2 grams daily. Cyanocobalamin should not be used in megaloblastic anemia of pregnancy. Administration of doses greater than 10 microgram daily may produce a hematologival response in patients with folate deficiency.
STORAGE
Store at temperature of not more than 30°C.
PACK SIZE : 10 x 10’s
